Osteoporosis treatment preferences and satisfaction in postmenopausal women: Denosumab compared with oral bisphosphonates

Abstract

Aim: This paper aims to investigate whether Denosumab is more effective in promoting adherence and satisfaction than oral bisphosphonates in the treatment of osteoporosis in postmenopausal women.

Methods: Electronic database - MEDLINE, PubMed, CINAHL, Wiley online Library, ProQuest Nursing and Allied Health), free text engines Google Scholar and Findit@Flinders and reference lists of retrieved papers were searched according to the inclusion and exclusion criteria. Twelve studies were ultimately selected.

Primary argument: The author analyses and critically appraises literature comparing two common osteoporotic medications: oral bisphosphonates and subcutaneous Denosumab in view of patients’ preferences and satisfaction. Findings from this review could provide suggestions for developing frameworks in clinical practice, identify strategies to improve patient adherence to treatment and develop policies promoting active patient involvement in treatment decisionmaking.

Results: Following thematic organisation of the studies, four major themes emerged: patient’s view on attributes on osteoporotic medications; patient satisfaction and preferences in oral bisphosphonates compared to Denosumab; adherence to treatment with oral bisphosphonates compared to Denosumab; and practice implications.

Conclusion: Findings from reviewed studies favor Denosumab over oral bisphosphonates as the preferred long-term treatment in postmenopausal women. Patients have a greater satisfaction with less frequent dosing, mode of administration and side effects of Denosumab.